Journal article
An Experimental Investigation of White Matter Venous Hemodynamics: Basic Physiology and Disruption in Neuroinflammatory Disease
SC Kolbe, SI Gajamange, JO Cleary, TJ Kilpatrick
Frontiers in Neurology | FRONTIERS MEDIA SA | Published : 2020
Abstract
The white matter is highly vascularised by the cerebral venous system. In this paper, we describe a unique blood oxygen-level dependent (BOLD) signal within the white matter using functional MRI and spatial independent components analysis. The signal is characterized by a narrow peak frequency band between 0.05 and 0.1 Hz. Hypercapnia, induced transient increases in white matter venous BOLD that disrupted the oscillation indicative of a vasocontractile mechanism. Comparison of the white matter venous BOLD oscillations between 14 healthy subjects and 18 people with perivenular inflammation due to multiple sclerosis (MS), revealed loss of power in the white matter venous BOLD signal in the pea..
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Grants
Awarded by NIH Blueprint for Neuroscience Research
Funding Acknowledgements
We sincerely thank all study participants for their time. We acknowledge the Traditional Owners of the land on which this research was conducted and pay respects to their Elders, past and present. We acknowledge the financial support for the research provided by the National Health and Medical Research Council (APP10009757, APP1054147), National Multiple Sclerosis Society (RG4211A4/2). Data were provided (in part) by the Human Connectome Project, WU-Minn Consortium (Principal Investigators: David Van Essen and Kamil Ugurbil; 1U54MH091657) funded by the 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research; and by the McDonnell Center for Systems Neuroscience at Washington University. A version of this manuscript has been released as a pre-print at bioRxiv (Kolbe et al. https://doi.org/10.1101/208751).